European 2_09 v7
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چکیده
Tobias Smollett’s final novel, The Expedition of Humphry Clinker, published in 1771, is commonly viewed as Smollett’s masterpiece, a mature work which marks a transition from the picaresque adventure narrative to the masterly handling of epistolary form. Part of Smollett’s achievement in Humphry Clinker is in re-fashioning the epistolary travel journal to the purposes of literary fiction while retaining the considerable scope of that genre. Smollett’s choice of the epistolary travel form enabled him to range across subjects as varied as social change and the effects of luxury, topographical detail, moral observation, the description of customs and manners, and reflections on human nature and ‘character’. It also allowed him to draw upon his considerable talents as novelist, travel writer, historian, satirist, and all round eighteenth-century man of letters. Humphry Clinker is a work of great technical skill in which Smollett juggles the multiple viewpoints of five narrators – the superficially misanthropic Welsh Squire Matthew Bramble, his nephew Jery and niece Lydia, the shrewish Tabitha Bramble, and her maid Winifred Jenkins – to achieve subtle effects of irony and humour. The formal accomplishment of Smollett’s work was noted in the great resurgence of interest in the author around the bicentenary of his death, when critics began to question the long tradition of biographical interpretation in Smollett criticism, and to shift focus towards formal elements of his work such as the unity or ‘economy’ of Smollettian narrative, the use of persona, or the modification of picaresque form.ii In this essay I wish to focus on two aspects of Humphry Clinker’s form, epistolary travel writing and Smollett’s treatment of character, in order to resituate the novel within the context of wider enquiries into man, specifically the interest in human diversity and the different ‘characters of mankind’ shown by the science of man in the late eighteenth century.
منابع مشابه
Serial blood-based analysis of AR-V7 in men with advanced prostate cancer.
BACKGROUND We previously showed that pretreatment detection of androgen receptor splice variant-7 (AR-V7) in circulating tumor cells (CTCs) from men with castration-resistant prostate cancer is associated with resistance to abiraterone and enzalutamide, but not to taxane chemotherapies. Here, we conducted serial measurements of AR-V7 and evaluated patterns of longitudinal AR-V7 dynamics over th...
متن کاملAnalytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer
BACKGROUND The androgen receptor splice variant-7 (AR-V7) has been implicated in the development of castration-resistant prostate cancer (CRPC) and resistance to abiraterone and enzalutamide. OBJECTIVE To develop a validated assay for detection of AR-V7 protein in tumour tissue and determine its expression and clinical significance as patients progress from hormone-sensitive prostate cancer (...
متن کاملAndrogen receptor splice variant V7 (AR-V7) in circulating tumor cells: a coming of age for AR splice variants?
Prostate cancer continues to be the most common non-cutaneous malignancy afflicting men in developed countries [1]. Although surgery or radiotherapy for the primary disease appears be curative at the time of initial treatment, upward of 25% of men will have metastatic or residual disease (ACS Facts and Figures 2015). Since the advent of prostate-specific antigen assays, the recurrence of the ca...
متن کاملRapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer.
PURPOSE Mechanisms mediating androgen receptor (AR) reactivation in prostate cancer that progresses after castration (castration-resistant prostate cancer; CRPC) and subsequent treatment with abiraterone (CYP17A1 inhibitor that further suppresses androgen synthesis) remain unclear. EXPERIMENTAL DESIGN Prostate cancer xenografts were examined to identify mechanism of progression after castrati...
متن کاملAR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.
BACKGROUND The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of androgen-receptor splice variant 7 messenger RNA (AR-V7) in circulating tumor cells from men with advanced prostate cancer would be associated with...
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